Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer.
Minnelide/Triptolide (TL) has recently emerged as a potent anticancer drug in non-small cell lung cancer (NSCLC).However, the precise mechanism of its action remains ambiguous.In this study, we elucidated the molecular basis Drainage and Suction Accessories for TL-induced cell death in context to p53 status.Cell death was attributed to dysfunction