Milk Protein Concentration Using Negatively Charged Ultrafiltration Membranes

Milk Protein Concentration Using Negatively Charged Ultrafiltration Membranes

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In this work, milk protein concentrate (MPC) was made using wide-pore negatively charged CHEESECLOTH ultrafiltration membranes.The charged membranes were used for a six-fold volume concentration of skim milk and subsequent diafiltration to mimic the industrial MPC process.The charged 100 kDa membranes had at least a four-fold higher permeate flux at the same protein recovery as unmodified 30 kDa membranes, which are currently used in the dairy industry to make MPC.

By placing a negative charge on the surface of an ultrafiltration membrane, the negatively charged proteins were HYALURONIC ACID SERUM rejected by electrostatic repulsion and not simply size-based sieving.Mass balance models of concentration and diafiltration were developed and the calculations matched the experimental observations.This is the first study to use wide-pore charged tangential-flow membranes for MPC manufacturing.

Additionally, a unique mass balance model was applied, which accurately predicted experimental results.